Macromolecular interactions provide frameworks for diverse cellular activities. We are trying to understand the molecular basis of macromolecular interactions using combination of techniques in structural biology, biochemistry, biophysics and cell biology.
Polyubiquitins where ubiquitin molecules are conjugated to each other with various linkages regulate a miliue of cellular processes including endocytosis, intracellular trafficking and DNA damage response. We are particularly interested in how polyubiquitin moieties are recognized by various ubiquitin binding domains.
Pneumonia is one of the leading causes for human death worldwide. We are attempting to identify novel virulence factors for pneumonia and to understand molecular mechanisms of those factors.
Plant stress fitness by artificial evolution
Plants have developed systems to tolerate both biotic and abiotic stresses for a long time. We seek further improvments of the plant stress fitness by an artificial evolution system.